1. Oct 13, 2020

Lower baseline IOP linked with less favorable laser trabeculoplasty response

Patients with a lower baseline intraocular pressure (IOP), angle recession, uveitis, and aphakia were less likely to have a favorable laser trabeculoplasty (LTP) response, according to a study.

In this retrospective cohort study, data from the Intelligent Research in Sight (IRIS®) Registry from 2013-2018 on patients undergoing LTP, were collected.

In the 263,480 eyes included, there was a mean baseline IOP of 19.1 +/- 5.0 mmHg, with a mean number of pre-LTP medications of 2.1 +/- 1.5.

Overall, the response rate was 36.9%. For patients with a baseline IOP > 24 mmHg, the response rate was 68.8%. A higher baseline IOP was associated with reduced odds of nonresponse whereas angle recession, uveitis, and aphakia increased the odds of a nonresponse.

Approximately 76% of patients who were nonresponders and were taking medication at baseline were taking fewer medications postoperatively.

The authors concluded that, “Future studies that analyze LTP responder survival and implementation lag would facilitate resource optimization in glaucoma therapy.

Chang TC, Parrish RK, Fujino D, et al. Factors associated with favorable laser trabeculoplasty response: IRIS Registry Analysis. Am J Ophthalmol. 2020; DOI:https://doi.org/10.1016/j.ajo.2020.10.004.