Acetaminophen infusion effective analgesic for cataract surgery
Acetaminophen infusion utilized as an analgesic for cataract surgery had lower side effects and higher surgeons’ satisfaction compared to dexmedetomidine, according to a study.
In this parallel randomized controlled clinical trial, 135 patients between the age of 50-80 years undergoing cataract surgery were randomized to receive acetaminophen (15 mg/kg), dexmedetomidine (0.5 μgr/kg), or normal saline (NS).
Researchers analyzed vital signs, blood pressure, arterial oxygen saturation, respiratory and heart rate at baseline, the start of surgery, 5 minutes after surgery, 10 minutes after surgery, 15 minutes after surgery, after arrival to the recovery room, 20 minutes after recovery, 40 minutes after recovery, and 60 minutes after recovery.
In patients who received dexmedetomidine, the level of respiratory depression was higher. There were no significant differences found between the 3 groups in heart rate and oxygen saturation percentage or pain intensity.
Moradi Farsani D, Mortazavi SA, Masjedi S, et al. Comparison between the Effects of Acetaminophen, Dexmedetomidine, and Normal Saline Infusion on Pain Severity after Cataract Surgery. Adv Biomed Res. 2022;11:71. doi: 10.4103/abr.abr_254_20. PMID: 36325174; PMCID: PMC9621349.
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