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Cataract/Anterior Segment

NSAID, corticosteroid combo reduces cystoid macular edema risk post-cataract surgery

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A combination of non-steroidal anti-inflammatory drugs (NSAID) and corticosteroids (CS) reduced the risk of developing cystoid macular edema (CME) after cataract surgery, according to a study.

Researchers utilized Pubmed, Cochrane Library, and Embase electronic databases to identify 24 relevant randomized controlled trials.

In non-diabetics and mixed populations, NSAIDs alone and in combination with CS, significantly reduced the risk of developing CME compared with CS alone.

In the ranking profiles, combined treatment demonstrated a significant advantage over the single drugs and was less likely to lead to the development CME. Compared with bromfenac and nepafenac, diclofenac was the most likely to reduce the odds of developing CME. Compared with betamethasone and fluorometholone, dexamethasone was the most likely to reduce the odds of developing CME.

Reference
Li SS, Wang HH, Wang YL, et al. Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs and corticosteroid drugs for prevention of cystoid macular edema after cataract surgery. Int Ophthalmol. 2022;doi: 10.1007/s10792-022-02426-y. Epub ahead of print. PMID: 36065039.

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