Should CXL be performed on early-stage patients with keratoconus?
The vision‐related quality of life of patients with early keratoconus remains high but sharply declines after disease progression and does not improve after corneal cross‐linking, according to a study.
In this combined prospective/cross‐sectional study, 56 patients with keratoconus took the Refractive Status and Vision Profile (RSVP) and the National Eye Institute Visual Functioning – 25 (NEI‐25) questionnaires. Overall, 26 patients had stable disease and 30 had progressive; 10 patients had undergone corneal cross‐linking.
A minor decline in vision‐related quality of life was found in patients with early keratoconus was found whereas patients with progressive keratoconus demonstrated a statistically significant decline, which did not improve after corneal cross‐linking.
The researchers concluded that the current strategy to perform corneal cross‐linking only after progression in patients with keratoconus should be re-evaluated.
Steinberg J, Bußmann N, Frings A, et al. Quality of life in stable and progressive ‘early‐stage’ keratoconus patients. Acta Ophthalmol. 2021;99:e196-e201.