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Cornea and External Disease

Topical Antibiotics Improve Clinical Cure Rates for Bacterial Conjunctivitis

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Administering topical antibiotics to patients with bacterial conjunctivitis results in both clinical and microbiological cure, according to an updated Cochrane review of 11 randomized, placebo-controlled trials involving nearly 3,700 individuals.

Investigators looked at trials that diagnosed bacterial conjunctivitis based on either clinical or microbiological findings. They examined clinical and microbiological cure rates — specifically, absence of symptoms or microbiological eradication. Among the findings:

  • An improved early clinical cure rate of 40% was observed in those treated with antibiotics; superior microbiological cure was also observed.
  • Antibiotics continued to produce benefit at days 6 to 10.
  • The absolute risk differences for early and late clinical cure were 11% and 9%, respectively.
  • Placebo patients experienced a 30% cure rate by day 5, and 41% by days 6 to 10.
  • No serious outcomes occurred in either group.

Kowalsky D, Wolfson A. Topical Antibiotics for Clinical and Microbiological Cure of Bacterial Conjunctivitis. [Published online ahead of print November 12, 2018]. Acad Emerg Med. doi: 10.1111/acem.13663.

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