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Dry Eye

Anti-androgen drugs may make dry eye worse in some patients

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Altered tear function tests, increased corneal and conjunctival staining scores, and worsening complaints of dry eye were noted in patients with prostate cancer receiving anti-androgen drugs, according to a study.

Researchers examined 64 male patients, including 31 who were on anti-androgen treatment for prostate cancer (Group A) and 17 who received only surgical treatment (Group B). A control group of 16 patients who had never received anti-androgen treatment (Group C) were matched for age.

The mean Schirmer’s values were 6.87mm in Group A, 11.41mm in in Group B, and 13.03mm in Groups C (P = 0.001) and tear film break up time (TBUT) was 5.45±2.01, 9.85±2.52 and 9.81±1.96 seconds, respectively (P=0.001).

In Group A Schirmer and TBUT were significantly lower, and corneal staining and OSDI questionnaire scores were higher than in Groups B and C (P < 0.01)..

Reference
Aydin Kurna S, Oflaz Hacisalihoglu A, Altun A, et al. Effects of systemic anti-androgen drugs on the ocular surface. J Fr Ophtalmol. 2022;S0181-5512(21)00473-3. doi: 10.1016/j.jfo.2021.06.007. Epub ahead of print. PMID: 35489988.

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