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Dry Eye/OSD

Study identifies 5 clinically meaningful dry eye disease subtypes

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Amongst 5 clinically meaningful subtypes of dry eye disease (DED) significant differences in demographics, symptoms, signs, and systemic disease associations were noted, according to a study.

In a secondary analysis of data from the DREAM study, a large multicenter randomized clinical trial evaluating omega-3 in treating symptomatic DED, 5 clinically meaningful DED subtypes were identified.

In the dream study, latent profile analysis was used to identify the subtype of 535 patients with moderate-to-severe DED based on baseline Ocular Surface Disease Index, tear break-up time (TBUT), anesthetized Schirmer’s test, corneal and conjunctival staining, and meibomian gland dysfunction (MGD).

The identified subtypes had significant differences in sex and race.
Subtype 1: Most severe DED signs; mild symptoms. Associated with Sjögren’s syndrome
Subtype 2: Mildest DED signs with the exception of MGD
Subtype 3: Most severe symptoms, unproportionable to DED signs
Subtype 4: Milder symptoms; milder MGD
Subtype 5: Severe MGD and TBUT; linked with rosacea

Reference
Yu K, Asbell PA, Shtein RM, et al; for Dry Eye Assessment and Management Study Research Group. Dry Eye Subtypes in the Dry Eye Assessment and Management (DREAM) Study: A Latent Profile Analysis. Transl Vis Sci Technol. 2022;11(11):13. doi: 10.1167/tvst.11.11.13. PMID: 36383391; PMCID: PMC9680588.

 

 

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