Macular vessel density reduction rate in POAG influenced by baseline measurements

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In patients with primary open angle glaucoma (POAG), the rate of macular vessel density (mVD) was significantly influenced by macular ganglion cell-inner plexiform layer (mGCIPL) thickness and parapapillary retinal nerve fiber layer (pRNFL) thickness measurements at baseline, according to a study.

In this prospective cohort study, 102 eyes with POAG were followed for 36.6 ± 6.4 months and the rates of progression were estimated by linear models.

The respective rate of progression by linear regression per month was -0.102±0.054 μm for mGCIPL thickness, -0.160±0.086 μm for pRNFL thickness, and -0.199±0.073 % mVD. The agreement in detection of progression was poor. Baseline mGCIPL thickness, baseline pRNFL thickness, and baseline mVD (P ≤ 0.001) significantly influenced the rate of progression of mVD. Baseline mVD was not a significant factor influencing the rates of progression of mGCIPL thickness and pRNFL thickness. Compared with mGCIPL and mVD, pRNFL thickness had a better survival probability (P = 0.025).

Ye C, Wang X, Chak-yan M, et al. Progression of macular vessel density in primary open angle glaucoma: a longitudinal study. Am J Ophthalmol. 2020; DOI:https://doi.org/10.1016/j.ajo.2020.10.008

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