Micro-sized allogeneic serum eye drops effective for dry eye disease
Both micro and conventional-sized allogeneic serum eye drops (SEDs) demonstrated similar improvements in dry eye disease (DED) symptoms, as measured by the Ocular Surface Disease Index (OSDI) score, according to a study.
In a randomized trial, 49 patients with DED were administered micro-sized SEDs (7 µl/unit) for 1 month, followed by a 1-month washout period, before receiving conventional-sized SEDs (50 µl/unit) for another month, or vice versa. The study focused on key parameters including the (OSDI) score, tear break-up time (TBT), tear production (TP), and the presence of corneal punctate lesions (CP).
Micro-sized SEDs demonstrated a significant improvement, reducing scores from 52 ± 3 to 41 ± 3, while conventional-sized SEDs exhibited a reduction from 54 ± 3 to 45 ± 3. The non-inferiority margin of 6 was successfully met by micro-sized SEDs.
Furthermore, the study found a significant enhancement in TBT with conventional-sized SEDs, as well as a positive impact on CP for both treatment groups. Tear production also showed a positive trend towards improvement in both groups. The conventional drop system received higher marks for user-friendliness, making it a more accessible option for patients.
Vermeulen C, van der Burg LLJ, van Geloven N, et al. Allogeneic Serum Eye Drops: A Randomized Clinical Trial to Evaluate the Clinical Effectiveness of Two Drop Sizes. Ophthalmol Ther. 2023;doi: 10.1007/s40123-023-00827-5. Epub ahead of print. PMID: 37843772.