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AAO
Retina

Prefilled syringes reduce rate of endophthalmitis after intravitreal injection

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Use of prefilled syringes (PFS) of anti–vascular endothelial growth factor (VEGF) therapies for intravitreal injections significantly reduces the rate of endophthalmitis compared to the use of a traditional glass vial, according to a poster presented at AAO 2022.

In this retrospective study, data from 294,862 injections were analyzed. Overall, there were 97 cases of endophthalmitis identified (0.033%), with 51 of them occurring in the vial group of aflibercept and ranibizumab (0.052%) and 24 occurring in the PFS group (0.018%).

The authors concluded that were PFS were associated with a decreased risk of endophthalmitis (OR 0.34; 95% CI, 0.21-0.56; P < 0.001).

Reference
Louis AM, et al. Impact of Prefilled Syringes and Masking on Post–Intravitreal Injection Endophthalmitis.Poster presented at: AAO 2022.

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