Volume of post-injection rinse doesn’t lead to significant differences in ocular surface irritation
The volume of washout rinse after povidone iodine (PI) application for intravitreal injections (IVI) does not significantly affect patients’ ocular surface irritation, according to a study.
The study found no significant differences in dry eye symptoms or objective dry eye findings between groups receiving different rinse volumes (3-mL, 10-mL, and 15-mL).
The study divided participants into 3 groups, with 51 receiving a 3-mL rinse, 45 receiving a 10-mL rinse, and 46 receiving a 15-mL rinse. The Ocular Surface Disease Index (OSDI) and the Standardized Patient Evaluation of Eye Dryness II (SPEED II) surveys were administered both before the injections and 24-72 hours post-injection.
Prior to the injections, there were no statistically significant differences in objective dry eye findings, including the Schirmer test (P = 0.788), tear break-up time (P = 0.403), and Oxford fluorescein grade (P = 0.424) between the study groups.
The results showed that dry eye symptoms, as indicated by reductions in OSDI and SPEED II scores, did not significantly differ between the study groups (P = 0.0690 and 0.6227, respectively).
Jamshidi F, Jin HD, Bruce A, et al. The effect of ocular rinse volume on surface irritation after povidone-iodine preparation for intravitreal injections: a randomized controlled trial. Int J Retina Vitreous. 2023;9(1):59. doi: 10.1186/s40942-023-00470-z. PMID: 37770983.