Corticosteroids for Bacterial Corneal Ulcers: Mixed Results
Using adjunctive topical corticosteroid therapy in eyes with bacterial corneal ulcers appears to be safe, according to a prospective, randomized, placebo-controlled trial involving 500 individuals. Such therapy might be particularly useful in eyes with severe ulcers or Pseudomonas infection. The findings were summarized in a recent article.
Primary outcomes of the trial were mixed (no change in best-corrected visual acuity at 3 months, but also no adverse events). An analysis of secondary outcomes shows situations where corticosteroids would be preferred and others where they should be avoided.
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Krader C, Lietman T. SCUT trial delves into corticosteroid role for bacterial corneal ulcers. Ophthalmology Times June 28, 2018.