Rebamipide improves accuracy of predicted postoperative refraction in dry eyes
The predicted refractive accuracy for cataract surgery in patients with dry eye was improved with preoperative 2% rebamipide ophthalmic suspension, according to a study. Rebamipide also significantly improved the corneal surface condition.
“Preoperative dry eye treatment with rebamipide may be an option for improving the accuracy of IOL calculation, particularly when using more refractive error-sensitive IOLs, such as trifocal IOLs,” said Takeshi Teshigawara, MD, PhD during a poster presentation at ASCRS 2022.
In this single-center, prospective, open-label study, 35 eyes undergoing cataract surgery were treated with rebamipide for 4 weeks before preoperative tests were completed. Predicted postoperative spherical equivalent (P-SE) as checked at baseline and 1 month after dry eye treatment.
The accuracy of the biometry readings for the achieved P-SE was within 0.25 D in 42.9% and 54.3%; within 0.5D in 71.4% and 88.6%; and within 0.75 D in 88.6% and 97.1% of eyes before and after rebamipide treatment, respectively.
A significantly negative correlation with the accuracy of P-SE was demonstrated with the central part of the cornea and corneal higher-order aberrations prior to treatment. The degree of improvement after treatment showed a significant positive correlation with the degree of improvement in the accuracy of P-SE.
Teshigawara T, et al. The Effect of Rebamipide on Refractive Accuracy of Cataract Surgery in Dry Eye Patients. Presented at: ASCRS 2022.