Over half of patients with dry AMD developed advanced disease in long-term analysis
Just over half of eyes with dry age-related macular degeneration (AMD) progressed to advanced AMD over nearly 9 years, with progression more common in older patients and those with thinner baseline central macular thickness, lower visual acuity, open-angle glaucoma, and certain subgroup factors linked to neovascular AMD or geographic atrophy, according to a study.
The analysis included 74 eyes from 47 patients with dry AMD, with a mean age of 74.6 years. Over a mean follow-up of 8.9 ± 0.4 years, 40 eyes (54.1%) progressed to advanced AMD. Of these, 25 eyes (33.8%) developed neovascular AMD and 22 eyes (29.7%) progressed to geographic atrophy.
Eyes that progressed belonged to older patients and showed a higher prevalence of open-angle glaucoma, as well as thinner baseline central macular thickness on optical coherence tomography. Smoking in patients with open-angle glaucoma was associated with a greater tendency toward neovascular AMD, while female patients with lower baseline best-corrected visual acuity were more likely to develop geographic atrophy.
Reference
Sadeghi E, Mahmoudinezhad G, Valsecchi N, et al. Long-Term Follow-Up of Dry Age-Related Macular Degeneration Patients. J Curr Ophthalmol. 2025;37(1):78-85. doi: 10.4103/joco.joco_41_25. PMID: 41334307; PMCID: PMC12668649.
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