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Glaucoma

Long-term topical latanoprost treatment for early POAG affects pupillary function

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The long-term topical latanoprost 0.005% treatment in early-stage primary open-angle glaucoma (POAG) has a slight mydriatic effect on the pupil, according to the results of a 2-year longitudinal study. Further clinical studies with larger patient cohorts are necessary to better understand the effects of latanoprost on pupillary functions, reported the researchers.

The prospective study involved 20 eyes of 20 treatment-naive subjects with early-stage POAG. After comprehensive ophthalmic examination, static and dynamic pupillometry measurements were performed before treatment, at the first follow-up visit (~1 month) and the second follow-up visit (~25 months). Dynamic parameters included resting diameter, amplitude, latency, duration, and velocity of pupil contraction and dilation. Static pupillometry parameters were pupil diameter (PD) in high-photopic, low-photopic, mesopic and scotopic conditions.

The results demonstrated that the velocity of pupil dilation significantly decreased during the first visit and the second visit of treatment compared to the pre-treatment visit. The resting PD was also significantly higher after the first visit and the second visit compared to the pre-treatment visit. However, the difference in resting PD measured between the first and second visits were not statistically significant and no significant changes in other dynamic parameters were found. In addition, a mild, but not significant, mydriatic effect was observed in PD measurements under scotopic, mesopic and low photopic lighting conditions after follow-up. None of the static and dynamic parameters correlate with age, changes in intraocular pressure or mean deviation values of visual field tests.

Reference
Bayraktar S, Hondur G, Şekeroğlu MA, Cengiz Özyurt B, Şen E. The long-term effects of topical latanoprost 0.005% treatment on pupillary functions: A 2-year longitudinal study. Eur J Ophthalmol. 2024 Jan 18:11206721241227780. doi:10.1177/11206721241227780.

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