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Study finds significant IOP reductions with iDose TR and MIGS procedures

Ophthalmology 360

Key Takeaways

  1. Combining iDose TR with either iStent infinite or canaloplasty significantly reduced IOP at 3 months in eyes with open-angle glaucoma.
  2. Mean IOP decreased from 19.0 mmHg at baseline to 15.3 mmHg overall, with significant reductions seen both with and without concurrent cataract surgery.
  3. Nearly 60% of eyes were medication-free at 3 months, including 67.7% of eyes that underwent combined cataract surgery

Combining the sustained-release travoprost implant iDose TR with either iStent infinite implantation or canaloplasty significantly reduced intraocular pressure (IOP) and dependence on topical IOP-lowering medications within 3 months, regardless of whether cataract surgery was performed concurrently, according to a study.

Across the overall cohort (N = 107), mean IOP decreased from 19.0 mmHg at baseline to 15.3 mmHg at 3 months (P < 0.0001). Among the 66 eyes that underwent concurrent cataract surgery, mean IOP decreased from 17.5 mmHg to 14.3 mmHg (P < 0.0001). In the 41 eyes that did not undergo cataract surgery, mean IOP decreased from 21.6 mmHg to 16.8 mmHg (P = 0.001).

At 3 months, 59.4% of eyes overall were free of topical IOP-lowering medications. Medication-free rates were 67.7% in the cataract surgery subgroup and 46.3% in the non-cataract surgery subgroup.

Similar reductions in IOP and medication use were observed among eyes treated with iDose TR combined with either iStent infinite or canaloplasty, with or without cataract surgery.

Reference
Funke C, CoHan C. A Multimodal Approach to Open-Angle Glaucoma with Travoprost Intracameral Implant and Minimally Invasive Glaucoma Surgery with or Without Concurrent Cataract Surgery. Ophthalmol Ther. 2026;doi: 10.1007/s40123-026-01408-y. Epub ahead of print. PMID: 42234082.

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