Episodic flares are common in many patients with chronic dry eye disease (DED). These can be triggered by any number of things and are associated with a rapid increase of dry eye symptoms, followed by prolonged elevation of inflammation. During an acute flare, a nonspecific innate immune response triggers ocular surface inflammation. In this literature review, researchers examine the role of epithelial cells, which are central to the innate immune response at the ocular surface, and their role in DED
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Perez VL, Stern ME, Pflugfelder SC, et al. Inflammatory basis for dry eye disease flares. Exp Eye Res. 2020; https://doi.org/10.1016/j.exer.2020.108294.