1. May 29, 2019

Patients Prefer Combination Drop Over Standard Regimen

Patients prefer using a compounded triple combination drop over a standard medication regimen for preventing infection and inflammation after routine cataract surgery, according to preliminary results from a prospective, randomly selected contralateral eye-controlled study presented at the 2019 ASCRS-ASOA annual meeting. Interim results were presented by Helga P. Sandoval, MD, director of research, Caroline Eyecare Physicians, Charleston, SC.

The study aims to compare use of the compounded drop containing prednisolone acetate 1%, gatifloxacin 0.5%, and bromfenac 0.075% (Pred-Gati-Brom LessDrops, Imprimis Rx), with its individual components (control group) undergoing bilateral, routine cataract surgery. Each participant uses the combination drop in one eye and the separate drops in the other eye.

At 1-month follow-up, the group of eyes treated with the combination drop versus the control group (n = 19) showed no difference in macular thickness or corneal pachymetry. Patients using the combination drop did not report any unanticipated adverse events and all patients said they preferred the combination drop regimen.

The study has a planned enrollment of 35 patients.


Sandoval HP. Combination drop therapy used as prophylactic treatment compared to standard drop regimen after routine phacoemulsification. Presented at: ASCRS-ASOA annual meeting; May 3-7, 2019; San Diego, CA.