Lotilaner 0.25% improves Demodex blepharitis outcomes while tea tree oil shows no benefit
Lotilaner ophthalmic solution 0.25% significantly improved Demodex mite density and eradication in patients with Demodex blepharitis, while over-the-counter tea tree oil (TTO) showed no benefit versus sham, according to a presentation at the Association of Cataract and Refractive Surgery (ASCRS) Annual Meeting.
The analysis included 9 randomized controlled trials identified through major databases and recent conference abstracts. Lotilaner 0.25% significantly reduced mite density compared with vehicle at both 2-4 weeks and 6-8 weeks (P < 0.0001), whereas TTO showed no significant effect at either timepoint.
Lotilaner also demonstrated higher odds of mite eradication versus vehicle at 2-4 weeks (OR 4.70; P < 0.0001) and 6–8 weeks (OR 9.60; P < 0.0001). In contrast, TTO did not significantly improve eradication rates compared with sham.
Reference
Burkhard Dick H, et al. Systematic Literature Review and Meta-Analysis of Lotilaner Ophthalmic Solution 0.25% and Tea Tree Oil As Treatments for Demodex Blepharitis. Poster presented at: ASCRS Annual Meeting; April 10–13, Washington, DC.
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