Patients with Sjögren’s disease-related dry eye may be distinguished from those with non-Sjögren’s dry eye primarily by worse ocular surface staining and complaints of dry mouth, according to a study.
Researchers compared 20 patients with Sjögren’s disease-related dry eye (SDDE), 47 with non-SDDE, and 29 healthy controls. All dry eye participants had diagnosed disease for at least 6 months, and Sjögren’s diagnoses met 2016 criteria. Participants completed validated questionnaires, and investigators assessed ocular surface and tear film parameters.
Among systemic symptom questionnaires, only the Profile of Fatigue and Discomfort Questionnaire (PROFAD) was able to distinguish between SDDE and non-SDDE groups. Of the 4 Sjögren’s Foundation-recommended review of systems questions, only reports of dry mouth differed significantly between the groups.
No mental health or ocular symptom questionnaires showed significant differences between patients with SDDE and those with non-SDDE.
Among clinician-measured ocular findings, only corneal fluorescein staining and conjunctival lissamine green staining scores were significantly worse in patients with SDDE.
Reference
Munar K, et al. Patient-Reported Symptoms Versus Clinician-Measured Signs to Distinguish Sjogren’s in Patients with Dry Eye. Presented at: ASCRS Annual Meeting; April 10–13, Washington, DC.
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