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Dry Eye

NOV03 eye drop effective in DED associated with MGD

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NOV03 (perfluorohexyloctane) ophthalmic drop significantly reduced signs and symptoms of dry eye disease (DED) associated with meibomian gland dysfunction (MGD) compared with hypotonic saline control, according to results of a randomized controlled trial.

In the study, 620 patients with a history of DED and signs of MGD were randomly assigned 1:1 to treatment with NOV03 (n = 311) or hypotonic saline (0.6%; n = 309) 4 times daily for 8 weeks.

The mean change in total corneal fluorescein staining and VAS dryness score from baseline to week 8 was statistically significantly greater for NOV03 compared with saline, with a statistically significant difference seen between groups as early as week 2.

Adverse events were similar between treatments; there were no serious adverse events or those leading to discontinuation of treatment.

Reference
Sheppard JD, Kurata F, Epitropoulos AT, et al; MOJAVE STUDY GROUP. NOV03 for Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction: the Randomized Phase 3 MOJAVE Study: NOV03 for Dry Eye Disease Associated With Meibomian Gland Dysfunction (69 characters; limit, 60). Am J Ophthalmol. 2023;S0002-9394(23)00098-3. doi: 10.1016/j.ajo.2023.03.008. Epub ahead of print. PMID: 36948372.

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