Early changes in OCTA microvascular, OCT structural parameters may predict nAMD outcomes

There are significant correlations between swept-source optical coherence tomography angiography (SS-OCTA) parameters and clinical outcomes in eyes with neovascular age-related macular degeneration (nAMD) administered a bimonthly intravitreal aflibercept regimen, according to a study.

The study found that certain structural and microvascular parameters, such as central subfield thickness (CST), 5 mm pigment epithelial detachment (PED) volume, macular neovascularization area, vessel density (VD), and vessel length density (VLD), were associated with changes in best-corrected visual acuity during different phases of treatment. Patients who experienced greater reductions in VD and VLD during the loading phase and those who had lower CST and PED volume after the first injection tended to have better visual acuity outcomes.

Reference
Park JB, Kim K, Kang MS, et al. Optical coherence tomography angiography biomarkers in a bi-monthly maintenance dosing aflibercept in patients with neovascular age-related macular degeneration. BMC Ophthalmol. 2023;23(1):314. doi: 10.1186/s12886-023-03039-4. PMID: 37438681; PMCID: PMC10337201.