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Triple-layer decellularized amniotic membrane linked to low recurrence and minimal complications

Ophthalmology 360

Key Takeaways

  1. The technique showed 0% recurrence at nearly 1 year of follow-up.
  2. No complications occurred, with reduced operative time and postoperative burden.

A glueless, sutureless pterygium excision technique using a triple-layer dehydrated, decellularized amniotic basement membrane with brief mitomycin-C exposure was associated with 0% recurrence and no reported complications at a mean follow-up of 394 days, according to a study.

The triple-layer dehydrated, decellularized amniotic basement membrane used in this study differs from traditional amniotic membrane tissue (AMT). The decellularization process removes the pro-inflammatory chorion and residual donor cellular debris, reducing immunogenicity while preserving extracellular matrix components such as collagen, fibronectin, and laminin. These structural proteins support anti-inflammatory cytokine and growth factor activity, which may aid epithelial adhesion and migration.

The analysis included 34 eyes from 33 patients who underwent pterygium excision with the dehydrated, triple-layer decellularized basement membrane. Patients reported minimal postoperative discomfort, and operative eyes demonstrated minimal subconjunctival injection. At a mean follow-up of 394 days (range, 174–668 days), no recurrences were observed (0/34 eyes). There were also no cases of pyogenic granuloma, infection, dellen, or corneal melt.

According to the authors, compared with traditional AMT and conjunctival autograft techniques performed with glue or sutures, the described approach reduced operative time, postoperative discomfort, follow-up visits, and topical steroid use, while also lowering costs without compromising outcomes.

Reference

McDonald M. A Retrospective Review of Glueless, Sutureless Pterygium Excision Using Biovance Triple-Layer Decellularized Amniotic Basement Membrane Tissue. Ophthalmol Ther. 2026;15, 771–780 (2026). https://doi.org/10.1007/s40123-026-01311-6.

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