Biomarker RANTES significantly lower in patients with geographic atrophy

Significantly lower levels of the biomarker RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted) were found in patients with geographic atrophy (GA) when compared to controls, according to a study.

Using data from a cohort of patients with GA from the Colorado Age-related Macular Degeneration (AMD) registry, researchers determined that plasma levels of RANTES in the control group were 10,204 [5799-19,554] pg/mL compared with 5435 [3420-9177] pg/mL in the GA group, a significant difference (P < 0.01)

There was no statistical difference between males and females in patients in the GA group when moderated by sex, the authors noted.

Reference
Fonteh CN, Palestine AG, Wagner BD, et al; University of Colorado Retina Research Group. RANTES (CCL5) in Patients With Geographic Atrophy Age-Related Macular Degeneration. Transl Vis Sci Technol. 2023;12(1):19. doi: 10.1167/tvst.12.1.19. PMID: 36633873; PMCID: PMC9840441.