Biomarker RANTES significantly lower in patients with geographic atrophy
Significantly lower levels of the biomarker RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted) were found in patients with geographic atrophy (GA) when compared to controls, according to a study.
Using data from a cohort of patients with GA from the Colorado Age-related Macular Degeneration (AMD) registry, researchers determined that plasma levels of RANTES in the control group were 10,204 [5799-19,554] pg/mL compared with 5435 [3420-9177] pg/mL in the GA group, a significant difference (P < 0.01)
There was no statistical difference between males and females in patients in the GA group when moderated by sex, the authors noted.
Fonteh CN, Palestine AG, Wagner BD, et al; University of Colorado Retina Research Group. RANTES (CCL5) in Patients With Geographic Atrophy Age-Related Macular Degeneration. Transl Vis Sci Technol. 2023;12(1):19. doi: 10.1167/tvst.12.1.19. PMID: 36633873; PMCID: PMC9840441.