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Geographic Atrophy

Ethnicity may play role in geographic atrophy lesion phenotype, growth rate

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Differences between Asians and non-Asians in geographic atrophy (GA) phenotype, associated features, and growth rate were identified in a multicenter, retrospective case series that sought to characterize GA by ethnicity.

Researchers analyzed baseline and last follow-up (≥ 2 years) characteristics of 144 patients (71 Asian patients and 73 non-Asian patients) with GA secondary to age-related macular degeneration in the absence of neovascularization.

Compared to non-Asians, Asians had:

-Thicker choroids
-Lower prevalence of any drusen
-Smaller GA area at baseline
-Fewer GA foci
-A slower GA lesion growth rate

Ethnicity, junctional zone fundus autofluorescence pattern, baseline GA area, and the number of GA foci were associated with GA lesion growth rate.

Reference
Teo KY, Fujimoto S, Sadda SR, et al. Geographic atrophy phenotypes in subjects of different ethnicity: Asia-Pacific Ocular Imaging Society Workgroup Report 3. Ophthalmol Retina. 2022;S2468-6530(22)00639-X. doi: 10.1016/j.oret.2022.12.013. Epub ahead of print. PMID: 36586466.

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