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AAO
Geographic Atrophy
Retina

GATHER 2: Avacincaptad pegol slows geographic atrophy growth

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The investigational geographic atrophy (GA) therapy avacincaptad pegol effectively slowed the rate of GA growth in patients with the disease, according to data from the Phase 3 GATHER 2 trial.

This is the first time an investigation therapy in GA has achieved the 12-month prespecified, primary endpoint in phase 3 studies.

During a presentation of the data at AAO 2022, Arshad M Khanani MD told attendees that avacincaptas pegol is a pegylated RNA aptamer designed to be a specific inhibitor of complement C5, which may slow inflammation and cell death associated with the development and progression of GA.

In the randomized phase 3 trial, 448 patients with GA with a non-center point involving GA lesion and GA in a part within 1500 um from the foveal center, were randomized the received treatment with monthly avacincaptas pegol (n = 225) or sham (n = 222). Baseline characteristics, including ocular characteristics, were well-balanced between groups.

In both groups, treatment fidelity through the first year was >90%.

The prespecified primary endpoint of mean rate of growth (slope) in GA area at 12 months was met with a high degree of statistical significance.

There was a 14.3% in mean rate of growth (Slope) in GA area and a 17.7% reduction in observed GA area in patients treated with avacincaptas pegol compared with patients treated with sham.

“We saw a separation of treatment effect early and that effect continued over time,” said Dr Khanani. “Both GATHER 1 and GATHER2 studies have shown us that we see a treatment effect early with AVA that increases over time. “

Reference
Khanani A, et al. GATHER2 Phase 3 Efficacy Results. Presented at AAO 2022.

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