New AI tools help monitor geographic atrophy in age-related macular degeneration

Automated optical coherence tomography (OCT), enhanced by artificial intelligence, is highly effective and reliable for monitoring the progression of geographic atrophy (GA) in patients with age-related macular degeneration, according to a study.

A recent study evaluated automated OCT monitoring against manual fundus autofluorescence measurements from the largest phase 3 clinical trial of complement inhibitor therapy for GA. The findings found that OCT-based automated retinal pigment epithelium loss measurements closely matched manual fundus autofluorescence assessments. In addition, ellipsoid zone loss appeared to exceed RPE loss, indicating it may have a role as a key marker in GA progression.

Reference
Mai J, Reiter GS, Riedl S, et al. Quantitative comparison of automated OCT and conventional FAF-based geographic atrophy measurements in the phase 3 OAKS/DERBY trials. Sci Rep. 2024;14(1):20531. doi: 10.1038/s41598-024-71496-y. PMID: 39227682; PMCID: PMC11372055.

This content is independent editorial sponsored by Astellas. Astellas had no input in the development of this content.