Nocturnal variability of IOP recorded with contact lens sensor linked with visual field loss in glaucoma

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Recording intraocular pressure (IOP)-related ocular dimensional change over 24-hours with a contact lens sensor (CLS) was associated with faster visual field progression in patients with primary open-angle glaucoma (POAG), according to a study.

In this retrospective, observational cohort study, a 24-hour CLS recording session from a single eye of 32 patients with POAG were analyzed, with an average of 11.6±5.6 SAP examinations available. The mean rate of mean deviation (MD) progression was 0.2±0.4 dB/year. Patients had a mean IOP of 17.8±4.2 mmHg with a mean of 1.2±1.0 IOP-lowering medications. Every 10-unit larger nocturnal variability of IOP-related ocular dimensional changes measured by CLS recording was significantly associated with -0.25±0.11 dB faster visual field loss in patients with POAG (P = 0.035).

The authors concluded that these recordings may be beneficial in assessing the risk of progression in patients with POAG.

Yang Z, Mansouri K, Moghimi S, et al. Nocturnal variability of intraocular pressure monitored with contact lens sensor is associated with visual field loss in glaucoma. J Glaucoma. 2020 Oct 29. DOI: 10.1097/IJG.0000000000001727. Epub ahead of print. PMID: 33137021.

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