Simplified electro-oculography method shows comparable results for screening retinal disease

A simplified electro-oculography (EOG) protocol integrated into full-field electroretinography (ffERG) offers comparable diagnostic accuracy to the standard EOG method for detecting retinal pigment epithelium (RPE) dysfunction, according to a study.

The study included 20 controls and 5 patients with Best vitelliform macular dystrophy (BVMD), and compared the standard EOG protocol to a screening version integrated into ffERG. The light peak-to-dark trough (LP) ratio, a key indicator of RPE dysfunction, was assessed. Results showed that both protocols yielded statistically significant differences in the LP

ratio between controls and patients with BVMD, with no significant difference in sensitivity (100%) or specificity (100%) between the methods.

The screening protocol not only performed equally well in detecting BVMD but was also found to be more patient-friendly, with participants reporting less discomfort and a simpler process compared to the standard method.

Reference
Djukanovic P, Jarc Vidmar M, Sustar Habjan M. Screening electro-oculography protocol as a part of full-field electroretinography. Doc Ophthalmol. 2024;doi: 10.1007/s10633-024-09994-7. Epub ahead of print. PMID: 39543056.