Link found between parenteral nutrition duration and ROP, updated prediction models promote improved screening

The duration of parenteral nutrition in premature infants (PND) has a significant impact on the development and severity of retinopathy of prematurity (ROP), according to a study.

Infants who receive parenteral nutrition for 14 days or more are at a higher risk of developing ROP and requiring treatment. The study also highlights the importance of using updated prediction models, such as the DIGIROP 2.0 models, which showed improved sensitivity in identifying high-risk infants for ROP treatment compared to other existing models like WINROP and G-ROP.

These findings provide evidence to support the consideration of PND and the use of updated prediction models in the management and screening of ROP, potentially improving outcomes for premature infants.

The study, which included 11,139 prematurely born infants from 2007 to 2020, aimed to assess the prognostic value of PND on ROP and update the Digital ROP (DIGIROP) 2.0 birth into prescreen and screen prediction models. Unlike previous models, the updated DIGIROP models included all ROP-screened infants, regardless of gestational age, and incorporated PND data.

Reference
Pivodic A, Holmström G, Smith LEH, et al. Prognostic Value of Parenteral Nutrition Duration on Risk of Retinopathy of Prematurity: Development and Validation of the Revised DIGIROP Clinical Decision Support Tool. JAMA Ophthalmol. Published online June 29, 2023. doi:10.1001/jamaophthalmol.2023.2336