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Most choroidal thickness change happens 2 weeks after aflibercept injection for nAMD

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Most choroidal thickness changes after intravitreal aflibercept injections in treatment-naïve patients with neovascular age-related macular degeneration (nAMD) occur after the first 2 weeks, according to a study.

In this prospective, open-label, single-arm pilot study, 21 treatment-naïve patients with nAMD received 3 monthly aflibercept injections (loading phase), followed by additional injections as needed.

Two independent observers manually measured CT) at baseline and 15, 30, 60, 90, and 365 days after the first injection.

There was a statistically significant reduction in CT at days 15, 90, and 365 compared to baseline. A major reduction in CT was observed at day 15 and in eyes with a thicker choroid at baseline.

There was no significant correlation between CT variation and the number of injections.

The study authors suggest that CT could be considered a potential biomarker “as it reflects the pharmacological effect of anti-VEGF drugs.”

Minnella AM, Centini C, Gambini G, et al. Choroidal Thickness Changes After Intravitreal Aflibercept Injections in Treatment-Naïve Neovascular AMD. Adv Ther. 2022;doi: 10.1007/s12325-022-02129-x. Epub ahead of print. PMID: 35597837.