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Home > Neurotrophic Keratitis > Eight-week cenegermin treatment linked to improved corneal outcomes in NK

Eight-week cenegermin treatment linked to improved corneal outcomes in NK

Ophthalmology 360

Key Takeaways

  1. An 8-week course of cenegermin was associated with improvements in both corneal sensation (116.5%) and corneal innervation (64.5%) from baseline.
  2. The analysis included 25 studies, with most patients having moderate (stage II) or severe (stage III) neurotrophic keratopathy.
  3. Greater relative improvements were observed in patients with more advanced disease, though variability in study design and small sample sizes may limit generalizability.

An 8-week course of cenegermin was associated with improvements in corneal sensation and corneal innervation in patients with neurotrophic keratopathy, according to a study.

In this analysis, investigators reviewed studies published between August 2018 and June 2024 that evaluated changes in corneal sensation or innervation following cenegermin treatment. A total of 25 studies met inclusion criteria, with a pooled mean patient age of 61.8 years. Most studies included patients with stage II (moderate) and stage III (severe) neurotrophic keratopathy.

Among studies reporting quantitative outcomes, 8 assessed corneal sensation and 3 evaluated corneal innervation. Using sample size–weighted analysis, the mean improvement from baseline to 8 weeks was 116.5% for corneal sensation and 64.5% for corneal innervation.

Reference
Fung SSM, Campos C, Weiss J, et al. Systematic Literature Review on the Effect of Cenegermin on Corneal Sensation and Innervation in Patients with Neurotrophic Keratopathy. J Ocul Pharmacol Ther. 2026;10807683261429005. doi: 10.1177/10807683261429005. Epub ahead of print. PMID: 41852024.

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