New treatment shows promise for fluid misdirection syndrome in pseudophakic eyes

Pars plana vitrectomy combined with irido-zonulo-hyaloidotomy (IZH) appears to be a safe and effective technique for the treatment of for fluid misdirection syndrome (FMS) in pseudophakic eyes, according to a study.

At the onset of this retrospective case series, 12 patients presented with a mean IOP of 38.2±9.8mmHg. Following the intervention, the IOP dropped significantly to 17.9±7.7mmHg (P < 0.0001) during a mean follow-up period of 4.9 ± 4.3 months.

The treatment outcomes were assessed based on 2 criteria. Complete success, defined as central anterior chamber (AC) deepening with an IOP of ≤21mmHg on 2 consecutive visits at least 1 week apart, was achieved in 50% of cases. Qualified success, which met the same criteria but allowed for the use of topical or systemic glaucoma medications, was reported in 83% of eyes.

The study found no statistically significant relationship between demographic data and clinical success.

Reference
Sellam A, Tourabaly M, Borderie V, Bouheraoua N. Evaluation of the efficacy and safety of pars plana vitrectomy with irido-zonulo-hyaloidotomy for malignant glaucoma. J Fr Ophtalmol. 2023;S0181-5512(23)00419-9. doi: 10.1016/j.jfo.2023.03.044. Epub ahead of print. PMID: 37777420.