Retinopathy of Prematurity

Weight Gain Acceleration Associated With Higher ROP Risk

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Weight gain acceleration is associated with a higher risk of retinopathy of prematurity (ROP), according to a new study in JAMA Ophthalmology.

The analysis used data from the Postnatal Growth and Retinopathy of Prematurity (G-ROP) study, and included 6,835 infants undergoing ROP examinations from 29 hospitals from January 2006 to June 2012. Mean birth weight was 1,086 g and mean gestational age was 27.9 weeks.

Researchers found that risk of severe ROP increased with late WGA up to approximately the 80th percentile of WGA. There was no association of ROP with late WGA among infants in the lowest early weight gain rate (WGR) tertile. However, among infants in the moderate and highest early WGR tertiles, moderate WGR tertiles had the highest risk of ROP (moderate early WGR tertile: adjusted odds ratio [OR], 1.38; 95% CI, 0.98-1.94; highest early WGR tertile: adjusted OR, 1.63; 95% CI, 1.02-2.60).

The findings must be validated in other cohorts, but have the potential to affect therapies.


Bal S, Ying GS, Tomlinson L, Binenbaum G, Postnatal Growth and Retinopathy of Prematurity (G-ROP) Study Group. Association of weight gain acceleration with risk of retinopathy of prematurity [published online ahead of print September 2019]. JAMA Ophthalmol. doi: 10.1001/jamaophthalmol.2019.3447.

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