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Retina

Aflibercept shows reduction in macular and choroidal thickness in patients with AMD

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Substantial improvements in visual acuity and notable reductions in both macular and choroidal thickness were seen among patients with neovascular age-related macular degeneration (AMD) who underwent intravitreal aflibercept injections, according to a study.

After receiving treatment with aflibercept, there was a significant improvement in the best-corrected mean visual acuity. The visual acuity, initially measured at 1.0 logarithm of the minimum resolution angle (logMAR) units, decreased to 0.55 logMAR after the treatment. Patients undergoing treatment exhibited a significant decrease in average macular thickness from 323 μm to 232 μm (P = 0.001), as well as a reduction in choroidal thickness from 206 μm to 172 μm (P = 0.031).

Statistically significant associations were found between the difference in pre- and post-treatment choroidal thickness and pretreatment values of macular thickness (P = 0.005) and choroidal thickness (P = 0.013).

Reference
Beraldo DP, Rezende MP, Alexander JG, et al. Correlations between subfoveal choroidal thickness, macular thickness, and visual outcome in neovascular age-related macular degeneration using swept source OCT: insights from intravitreal aflibercept treatment. Int J Retina Vitreous. 2023;9(1):70. doi: 10.1186/s40942-023-00506-4. PMID: 37968771.

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