Retinopathy of Prematurity

Conbercept Lowers Recurrence Rates in Patients with Retinopathy of Prematurity

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In patients with retinopathy of prematurity (ROP), treatment with conbercept resulted in less recurrence and longer treatment intervals compared with treatment with ranibizumab, according to a study published in

In this retrospective study, 625 patients treated for ROP with either intravitreal conbercept (n = 283 eyes) or ranibizumab (n = 916 eyes) who were followed for ≥12 months were included.

In zone I ROP and aggressive posterior ROP (APROP), the recurrence prevalence was 49.09% and the recurrence interval was 7.87 ± 0.65 weeks in the group treated with ranibizumab and 28.57% and 10.6 ± 1.53 weeks, respectively, in the group treated with conbercept.

Recurrence was significantly higher in patients treated with ranibizumab in Zone I ROP and APROP (P = 0.006) and Zone II ROP (P < 0.001) compared with those treated with conbercept. The time to recurrence was significantly longer in patients treated with conbercept compared to those treated with ranibizumab (P < 0.001). No significant difference in the rate of retinal vascularization was reported (P = 0.441).



Cheng Y, Zhu X, Linghu D, et al. Comparison of the effectiveness of conbercept and ranibizumab treatment for retinopathy of prematurity. Acta Ophthalmol. 2020;doi.org/10.1111/aos.14460

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