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Conference Roundup

Broluczimab improves persistent macular fluid in previously treated wet AMD eyes

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Switching to broluczimab after prior treatment with aflibercept or bevacizumab significantly reduced intraretinal and subretinal fluid in eyes with neovascular age-related macular degeneration (wet AMD), according to real-world data presented at the 2021 ASRS Annual Meeting.

In this retrospective case series, 48 eyes with wet AMD that had been previously treated with aflibercept (IVA-IVBr group) and 10 eyes with wet AMD that had been previously treated with bevacizumab (IVBe-IVBr group), were switched to broluczimab due to persistent fluid after ≥3 prior anti-VEGF injections. There was a mean of 6 weeks between the last injection and the first injection of broluczimab.

In eyes switched from aflibercept to broluczimab, after a mean of 6 weeks post-initial injection, mean central subfield thickness (CSFT) improved from 340 to 305 mm (P < 0.001). At this time, 31% of eyes had no fluid, 42% had reduced fluid, 25% had stable fluid, and 2% had increased fluid. In the 26 eyes that had 3 broluczimab injections, mean CSFT went from 325 to 277 mm (P = 0.001) and 24% of eyes had no fluid at the last follow-up visit.

In eyes switched from bevacizumab to broluczimab, after a mean of 6 weeks post-initial injection, CSFT improved from 401 to 325 mm (P = 0.009). At this time, 30% of eyes had no fluid and 70% had reduced fluid. In the 4 eyes that had 3 broluczimab injections, mean CSFT went from 375 to 275 mm (P = 0.001) and 50% of eyes had no fluid at the last follow-up visit.

In the IVA-IVBr group, mean logMAR at baseline was 0.44 and at the fourth visit was 0.40. in the IVBe-IVBr group, it was 0.33 and 0.35, respectively.

Reference
Hussain RM, et al. Real World Experience of Brolucizumab for Persistent Macular Fluid in Neovascular Age-Related Macular Degeneration After Prior Anti-VEGF Treatments. Presented at: 2021 ASRS Annual Meeting.

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