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Dry Eye/OSD

Dry eye symptom improvement reported after fecal microbial transplant

Posted on July 12, 2021
Dry eye symptom improvement reported after fecal microbial transplant

Fecal microbial transplant (FMT) improved dry eye symptoms in half of the patients with immune-mediated dry eye in a new study.

In this open-label, non-randomized clinical trial, 10 patients with dry eye symptoms and s criteria for Sjögren’s or positive early Sjögren’s markers underwent 2 FMTs from a delivered via enema, 1 week apart.

Significantly different gut microbiome profiles between patients and the donor were noted at baseline, with a decreased abundance of genera Faecalibacterium, Prevotella, and Ruminococcus and an increased abundance of genera Alistipes, Streptococcus, and Blautia in patients compared to the donor. After FMT, 8 subjects had gut microbiome profiles closer to the donor’s profile.

Overall, gut microbiome profiles were found to be more like the original recipients’ than the donor’s microbiome during the follow-up period; however, during the first 3 months, certain phyla, classes, and genera OTU numbers remained more similar to the donors profile.

Dry eye symptoms 3 months after FMT were subjectively reported by 5 patients.

No adverse events were found with FMT.

Reference
Watane A, Cavuoto KM, Rojas M, et al. Fecal microbial transplant in individuals with immune-mediated dry eye. AM J Ophthalmol. 2021; DOI:https://doi.org/10.1016/j.ajo.2021.06.022

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