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Dry Eye/OSD

Proxymetacaine response may help differentiate between DED, ocular neuropathic pain

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Use of topical Proxymetacaine in patients with ocular surface disease may help eyecare practitioners categorize dry eye disease (DED) and ocular neuropathic pain (ONP), according to a study.

In this study, 21 patients with symptoms of DED were treated with Proxymetacaine Hydrochloride 2%. Thirty seconds after instillation, subjective response was used to categorize patients as DED, ONP, or mixed DED/ONP. Primary DED was identified in 12 patients and ONP in 9 patients.

Amongst the 12 patients recruited from ophthalmologic outpatient clinics, 43% had features of neuropathic pain compared to 44% of patients (N = 9) in primary care optometric services.

Reference
Forristal MT, Stephenson KAJ. Differentiating primary dry eye disease from ocular neuropathic pain: implications for symptom management. Clin Exp Optom. 2022; doi: 10.1080/08164622.2022.2111199. Epub ahead of print. PMID: 36004515.

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