Satin Use, Dyslipidemia Linked to Dry Eye Disease

Satin use or dyslipidemia is associated with an increased risk of having dry eye disease (DED), according to an article published in American Journal of Ophthalmology.

In this retrospective, case-controlled study, 39,336 patients were included after excluding for confounding risk factors for DED. Of the 39,336 patients, 3399 were diagnosed with dry eye disease with 751 (1.9%) having low intensity statin regimens, 2655 (6.8%) having moderate intensity statin regimens, and 1036 (2.6%) having high intensity statin regimens. Their odds of carrying a diagnosis of DED were 1.39 (1.13,1.72), 1.47 (1.30,1.65), and 1.46 (1.21,1.75), respectively.

Total cholesterol >200 was found in 4558 (11.6%) of patients, HDL <40 in 2078 (5.3%) of patients, LDL >130 in 2756 (7.0%) of patients, and TGs >150 in 2881 (7.3%) of patients. Their odds of carrying a diagnosis of DED were 1.66 (1.52,1.82), 1.45 (1.26,1.67), 1.55 (1.39,1.74), and 1.43 (1.27,1.61), respectively.

Reference
Aldaas K, Ismail OM, Hakim J, et al. Association of dry eye disease with dyslipidemia and statin use. Am J Ophthalmol. 2020; DOI:https://doi.org/10.1016/j.ajo.2020.05.007