Ab interno microhook trabeculotomy lowers intraocular pressure (IOP) and reduces medication use over 12 months in patients with secondary glaucoma, according to a study.
The retrospective study included 39 patients with eyes with exfoliation glaucoma (n = 18), uveitic glaucoma (n = 15), and steroid-induced glaucoma (n = 6). Procedures were performed either as standalone trabeculotomy or combined with cataract surgery.
Researchers tracked IOP and medication use before surgery and at multiple intervals up to 12 months. Mean preoperative IOP was 25.4 mmHg, which decreased to 14.9 mmHg at 12 months. Medication scores also declined from 4.2 to 3.1 over the same period (P < 0.05). The mean IOP reduction rate at 12 months was 32.4%, and Kaplan-Meier analysis showed a 60.3% survival rate for maintaining IOP control.
Cox modeling identified older age and pseudophakia as factors linked with better postoperative IOP control. Anterior chamber hemorrhage occurred in 35.9% of cases.
Reference
Aoyama Y, Aihara M, Sakata R. Efficacy and Safety of Initial Outflow Reconstruction Using Ab Interno Microhook Trabeculotomy: A Retrospective Study in Secondary Glaucoma. Clin Ophthalmol. 2025;19:4219-4229. doi: 10.2147/OPTH.S553475. PMID: 41256873; PMCID: PMC12620511.
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