Trabeculectomy provides better long-term intraocular pressure (IOP) control and higher complete success rates than canaloplasty in patients with open-angle glaucoma, but it carries a greater risk of complications, while canaloplasty remains a safer alternative when moderate IOP control and ongoing medication are acceptable, according to a study.
A follow-up to the original Trabeculectomy versus Canaloplasty (TVC) trial re-evaluated patients from the 2015 TVC trial cohort after an average of 11 years.
Trabeculectomy achieved lower median IOP (10.0 mmHg vs 14.0 mmHg) and higher complete success rates than canaloplasty, though the difference did not reach statistical significance. Qualified success rates were similar between the procedures. Patients who underwent trabeculectomy also required fewer medications on average, but experienced a higher rate of complications, including 2 cases of hypotony maculopathy.
Reference
Verma-Fuehring R, Matlach J, Klink T, et al. Long-term outcomes of trabeculectomy versus canaloplasty in open-angle glaucoma – an 11-year follow-up of the TVC study cohort. BMC Ophthalmol. 2025;25(1):340. doi: 10.1186/s12886-025-04183-9. PMID: 40524153.
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