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Glaucoma

New preservative-free eye drop improves outcomes for glaucoma patients

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The preservative-free Dorzolamide/Timolol combination significantly reduces intraocular pressure (IOP) and improves ocular health in patients with glaucoma, according to a study.

This 3-month, multicenter, prospective cohort study included 382 patients with ocular hypertension or glaucoma treated with a single-dose, preservative-free (PF) Dorzolamide/Timolol combination.

There was a significant reduction in intraocular pressure (IOP), with a mean decrease of 1.9 mmHg (P < 0.001). Ocular abrasions dropped from 30.6% to 1.3%, while normal aqueous tear production increased from 24.1% to 79.4%. Ocular Surface Disease Index scores improved, decreasing from a median of 41.7 to 12.5 (P < 0.001). Tear break-up time increased from 9 to 12.3 seconds over 12 weeks.

Overall, the preservative-free Dorzolamide/Timolol combination demonstrated significant reductions in IOP and improved tolerability.

Reference
Lazreg S, Assaf AH, Abdelrahman AM, et al. Efficacy and safety of preservative-free anti-glaucomatous eye drops (dorzolamide/timolol) in ocular hypertension and/or glaucoma. Int Ophthalmol. 2025;45(1):30. doi: 10.1007/s10792-025-03411-x. PMID: 39832060.

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