Which glaucoma type is linked with more ocular surface disease symptoms?

Compared with other types of glaucoma, patients with pseudoexfoliative glaucoma (PEXG) have a higher frequency of signs of ocular surface disease (OSD), according to a study.

Researchers utilized the OSDI (ocular surface disease index) questionnaire in 58 patients with non-PEXG and 58 patients with PEXG. In addition, the presence and severity of OSD signs were recorded

Older participants with PEXG had lower central corneal thickness (CCT) values, a more advanced glaucoma stage, and required more intraocular pressure (IOP) lowering drops.

The prevalence of conjunctival hyperemia was 74.5% in patients with non-PEXG compared with 94.8% in patients with PEXG; eyelid redness prevalence was 70.7% compared with 96.6%; conjunctival prevalence was 74.1% compared with 93.1%; corneal fluorescein staining prevalence was 81% compared with 93.1%; and abnormal Tear breakup time prevalence was 82.8% compared with 87.9%.

After adjusting for confounder, eyelid redness was the only parameter significantly associated with PEXG; it was found to be 11 times more likely in patients with PEXG.

Reference
Dermenoudi M, Matsou A, Keskini C, et al. Ocular Surface Disease Signs and Symptoms in Patients with Pseudoexfoliative Glaucoma: A Case-Control Study. Vision (Basel). 2022;6(1):11. doi: 10.3390/vision6010011. PMID: 35225970; PMCID: PMC8883900.