Fluid-filled modular accommodating IOL prevents overall capsular bag opacification in animal study

In a rabbit model, a fluid-filled modular accommodating intraocular lens (IOL) maintained an open and expanded capsular bag, preventing overall capsular bag opacification while retaining uveal and capsular biocompatibility, according to a study.

In this experimental study, bilateral phacoemulsification was performed on 8 rabbits with 1 eye receiving the test IOL (Juvene; LensGen) and the other a hydrophobic acrylic control IOL (SA60AT).

Up to 6 months postoperatively, uveal biocompatibility was similar between the groups. In the test group, anterior capsule opacification was absent and posterior capsule opacification (PCO) was significantly less than the control group for the duration of the study.

At 6 months, central PCO score was 0.12 ± 0.23 and 4.0 ± 0 with the test IOL and the control IOLs, respectively. A histopathologic examination found the relative lack of capsular opacification in test eyes compared to controls as well the absence of toxicity in any eye.

Reference
Bontu S, Werner L, Kennedy S, et al. Long-term uveal and capsular biocompatibility of a new fluid-filled, modular accommodating intraocular lens. J Cataract Refract Surg. 2021;47(1):111-1117doi.org/10.1097/j.jcrs.0000000000000391