Late-Stage AMD

Subtypes of neovascular age-related macular degeneration

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A recent review identified the common characteristics of different subtypes of neovascular age-related macular degeneration (nAMD) according to macular neovascularisation (MNV) subtypes. Below are the major findings that may aide in the prognosis and management of patients with nAMD.

Type 1 MNV
-Linked with better long-term outcomes
-More intense anti-vascular endothelial growth factor dosing is usually needed

Type 2 MNV
-Usually responds quickly to treatment
-Fibrotic scars are more likely to form, possibly leading to poorer outcomes

Type 3 MNV
-Often highly sensitive to anti-VEGF treatment
-Compared with other subtypes, may be linked with a higher incidence of outer retinal atrophy.

Mathis T, Holz FG, Sivaprasad S, et al. Characterisation of macular neovascularisation subtypes in age-related macular degeneration to optimize treatment outcomes. Eye. 2022;https://doi.org/10.1038/s41433-022-02231-y.