Lens capsular flap transplantation potential initial treatment for large macular holes

Long-term outcomes of lens capsular flap transplantation (LCFT) as a primary treatment for large macular holes (MHs) suggest that it may help improve closure rate and visual outcomes, according to a study.

In this retrospective study, 13 eyes that underwent LCFT as primary treatment for large MHs (autologous LCFT in 8 eyes; allogenic LCFT in 5 eyes) were included. All included eyes underwent standard 23-gauge vitrectomy, internal limiting membrane peeling, LCFT, and 15% perfluoropropane tamponade. Autologous whole blood was applied in 7 eyes to make the LCT intact. For 2 weeks postoperatively, patients maintained a face-down position.

The mean preoperative MHs diameter was 979.42 ± 388.28 µm. Patients were followed for a mean of 19.57 ± 6.24 months (range: 12.0-32.2 months).

All eyes had the macular hole successfully closed. Preoperative median best-corrected visual acuity was 1.76 (interquartile range, 1.23-1.91) logarithm of the minimum angle of resolution (median Snellen acuity: 20/1,150) and increased to 1.16 ± 0.47 logarithm of the minimum angle of resolution (mean Snellen acuity: 20/290) (P < 0.01) at the last follow-up.

Reference
Peng J, Chen C, Zhang L, et al. Lens capsular flap transplantation as primary treatment for closure of large macular holes. Retina. 2022;42(2):306-312. doi: 10.1097/IAE.0000000000003315. PMID: 35050929.