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Ocular Surface Disease

New study explores efficacy of different ocular lubricants in reducing tear osmolarity

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Ocular lubricants, particularly preservative-free options like Siccafluid, Optive Fusion unique dose (UD), and Systane Ultra UD, demonstrate effectiveness in reducing tear film osmolarity and potentially offering relief for individuals suffering from Dry Eye Disease (DED), according to a study. By disrupting the hyperosmolar environment associated with DED, these lubricants may help alleviate inflammation and improve the ocular surface’s health, offering a promising avenue for managing this increasingly prevalent condition.

Using Dry Eye Workshop II (DEWSII) diagnosis framework, the study delves into DED as a multifactorial condition impacting tear film homeostasis on the ocular surface. The research aims to evaluate the short-term effects of 5 commercially available ocular lubricants on disrupting the hyperosmolar environment associated with DED and potentially offering treatment benefits.

Conducted on 300 eyes belonging to 150 patients, the study compared the impact of 5 preservative-free lubricants against a control group. The results, obtained within 15 minutes of application, showcased promising findings. All lubricants effectively reduced tear film osmolarity, contrasting with the control group, which exhibited an increase in average osmolarity without lubricant use.

Among the lubricants tested, Siccafluid emerged as particularly effective, demonstrating the most substantial osmolarity reduction with an average decrease of 11.54 mOsm/L after 15 minutes. Statistically significant results were observed for Siccafluid, Optive Fusion unique dose (UD), and Systane Ultra UD, while Hyabak and Freegen preservative-free (PF) exhibited lower significance.

The study underscores the importance of disrupting the hyperosmolar environment to mitigate inflammation associated with DED. By interrupting this cycle, ocular lubricants show promise in improving the hyperosmolar environment of the ocular surface, at least in the immediate post-application phase.

Reference
Muñoz EC, Patiño AO, Marín DJ, et al. Immediate Impact on Tear Osmolarity Following the Application of Different Ocular Lubricants in Patients Experiencing Moderate Dry Eye Symptoms. Cornea. 2024 Mar 15. doi: 10.1097/ICO.0000000000003493. Epub ahead of print. PMID: 38488642.

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