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Oculoplastics-ASOPRS

Baseline imaging may predict teprotumumab response

Posted on December 2, 2021

Total rectus volume is predictive of proptosis reduction following treatment with teprotumumab in patients with thyroid eye disease (TED), according to a study that examined potentially predictive baseline imaging characteristics.

Of the 25 patients included, 17 (68%) achieved ≥2 mm reduction in proptosis after treatment with teprotumumab. These patients had significantly greater medial rectus, inferior rectus, superior rectus, and total rectus volume compared to those who did not achieve ≥2 mm reduction in proptosis.

Total rectus volume was the only significant predictor of ≥2 mm reduction in proptosis following treatment with teprotumumab.

Reference
Roelofs K, et al. Radiologic Predictors of Response to Teprotumumab. Presented at: ASOPRS 52nd Annual Fall Scientific Symposium.

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