Patients with peripapillary pachychoroid syndrome experience decreased choroidal thickening

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Patients with peripapillary pachychoroid syndrome (PPS), a pachychoroid disease spectrum variant, experienced decreased choroidal thickening throughout the course of the disease, according to a study.

In this retrospective study, visual acuity (VA), retinal thickness, and choroidal thickness were evaluated in 56 eyes of 35 patients with PPS at baseline, 6 months, and final follow-up (mean follow-up of 27±17 months).

The median VA was 20/36 at baseline and stayed stable through the study.

Subfoveal, 1.5mm nasal to the fovea, and 3.0mm nasal to the fovea retinal thickness significantly decreased related to areas of increased thickening at baseline. Subfoveal choroidal and 1.5mm nasal to the fovea thickness decreased significantly. Over follow-up, VA remained stable in the 43 eyes treated with modalities including antivascular endothelial growth factor injection and photodynamic therapy.

A characteristic of PPS was an isolated peripapillary fluid pocket in the outer nuclear layer.

Xu D, Garg E, Lee K, et al. Long-term visual and anatomic outcomes of patients with peripapillary pachychoroid syndrome. B J Ophthalmol. 2020. DOI: 10.1136/bjophthalmol-2019-315550

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